Cri du Chat (Cat Cry) Syndrome is French for CRY OF THE CAT because of the _____ that about half the affected infants make. catlike cry. Symptoms of CRI DU CHAT (Cat Cry) Syndrome. Microcephaly (an abnormally small head) - congenital heart disease - Severe mental retardation. Causes. Diagnosis. Treatment. Prognosis. XYY syndrome (Jacobs syndrome or 47,XYY) is a genetic condition that occurs when a person assigned male at birth is born with an extra copy of the Y chromosome in some or all of their cells. Males are usually born with one X and one Y chromosome. About 1 in 1,000 males are born with XYY syndrome and may Cri du chat syndrome results from a deletion of the short arm of chromosome 5. Structural Chromosomal Abnormalities. Damage or changes to the structure of the chromosomes can also lead to health problems and birth defects. Cell functions may cease when large segments of DNA are missing or added to chromosomes. Other symptoms of cri du chat may include: Low birth weight. Delayed growth. Feeding difficulties, such as poor sucking, difficulty swallowing ( dysphagia) and GERD. Weak muscle tone ( hypotonia ). Curvature of the spine ( scoliosis ). Heart defects. Developmental delays, such as head control, PMID: 16473053. 10.1016/j.ejmg.2005.12.004. The aim of this report is to provide an update on the natural history of the Cri du Chat Syndrome by means of the Italian Register (I.R.). Two hundred twenty patients were diagnosed by standard cytogenetic methods and 112 of these were also characterised by molecular-cytogenetic investigation (FISH). noun. ˌkrē-du̇-ˈshä-, -də-. : an inherited condition characterized by a mewing cry, intellectual disability, physical anomalies, and the absence of part of a chromosome. called also cat cry syndrome. Cri-du-chat syndrome is caused by a deletion of the end of the short (p) arm of chromosome 5. This chromosomal change is written as 5p-. The signs and symptoms of cri-du-chat syndrome are probably related to the loss of multiple genes in this region. Researchers have not identified all of these genes or determined how their loss leads to the Cri Du Chat. Cri Du Chat syndrome is a rare chromosomal abnormality that affects an arm of chromosome number five. Other well-known names of the syndrome include; 5p minus, 5p monosomy, and Lejeune's Syndrome. The words Cri Du Chat translate in French to "cry of the cat," this is referring to the distinct cry of children burdened by this Cri du Chat Syndrome (CdCS) was first described c by J. Lejeune et al., in 1963 as a genetic, chromosomal disease that resulted from the deletion of variable sizes in the short arm of chromosome 5 (Orphanet). Behavioral Symptoms also develop into the phenotype of Cri du Chat-diseased children. These children often have hyperactivity Congenital anomalies, growth deficiency, and intellectual disability are among the findings observed in persons with chromosome abnormalities, although some cytogenetic aberrations have little to no clinical effect (approximately 1:500 healthy people have a balanced chromosome rearrangement [ 1 ]). Advances in human cytogenetics are u20O0V.